Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: a follow-up study

被引:187
作者
Leidig-Bruckner, G
Hosch, S
Dodidou, P
Ritschel, D
Conradt, C
Klose, C
Otto, G
Lange, R
Theilmann, L
Zimmerman, R
Pritsch, M
Ziegler, R
机构
[1] Univ Heidelberg, Dept Internal Med, D-69115 Heidelberg, Germany
[2] Univ Heidelberg, Dept Endocrinol & Metab, D-69115 Heidelberg, Germany
[3] Univ Heidelberg, Dept Gastroenterol, D-69115 Heidelberg, Germany
[4] Univ Heidelberg, Dept Cardiol, D-69115 Heidelberg, Germany
[5] Univ Heidelberg, Dept Med Biometry, D-69120 Heidelberg, Germany
[6] Univ Heidelberg, Dept Surg, D-69120 Heidelberg, Germany
[7] Univ Heidelberg, Dept Thorac & Cardiac Surg, D-69120 Heidelberg, Germany
关键词
D O I
10.1016/S0140-6736(00)03641-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Osteoporosis and related fractures are a major complication after organ transplantation. The aim of this study was to find out the frequency and predictors of osteoporotic fractures after cardiac or liver transplantation. Methods 235 consecutive patients who had a cardiac transplant (n=105; 88 men, 17 women) or a liver transplant (130; 75 men, 55 women) were followed. Vertebral fractures were assessed by a standardised analysis of spinal radiographs before and annually after transplantation. Clinical and non-vertebral fracture data were noted from hospital records. Findings in the first and second years after transplantation, the proportion of patients (Kaplan-Meier estimates) who had at least one Vertebral fracture was slightly higher in the cardiac group (first year 21%, second year 27%) than in the liver group (first year 14%, second year 21%). in the third and fourth years, one third of patients from both groups had had one or more vertebral fractures. Non-vertebral fractures occurred in nine patients (7%) after liver transplantation and avascular necrosis of the hip head in three patients (3%) after cardiac transplantation. In both groups, no dose-dependent effect of immunosuppressive therapy on fracture development could be identified. Independent predictors assessed by multivariate analysis were age (hazard ratio [95% CI] increase of 5 years, 1.71 [1.1-2.7]) and lumbar bane-mineral density (decrease of 1 SD t score, 1.97 [1.2-3.2]) in cardiac transplantation patients, and vertebral fractures before transplantation (6.07 [1.7-21.7]) in the liver group. Interpretation The high frequency of osteoporotic fractures in the 2 years after transplantation and the limitations of reliable fracture-risk predictions, show the need to investigate preventive therapies.
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页码:342 / 347
页数:6
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