Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins

被引：23

作者：

Athanasiadou, Anastasia

Stamatopoulos, Kostas ^{[1
]}

Gaitatzi, Maria

Stavroyianni, Niki

Fassas, Athanasios

Anagnostopoulos, Achilles

机构：

[1] G Papanicolaou Hosp, Hematol Dept, Thessaloniki 57010, Greece

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 03期

关键词：

chronic lymphocytic leukemia; cytogenetic diagnosis; FISH; immunoglobulin genes; hematopoietic recovery;

D O I：

10.3324/haematol.11872

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.

引用

收藏

页码：473 / 474

页数：2

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