Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli

被引：55

作者：

Morgan-Linnell, Sonia K. ^{[1
]}

Zechiedrich, Lynn ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 11期

关键词：

D O I：

10.1128/AAC.00647-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In defined, isogenic strains, fit least three mutations, two of which must be in gyrA, were required to exceed the CLSI breakpoint for fluoroquinolone resistance. Strains with double mutations in both gyrA and parC had even higher MICs of fluoroquinolones than strains with totals of three mutations.

引用

页码：4205 / 4208

页数：4

共 21 条

[1]

APPLEYARD RK, 1954, GENETICS, V39, P440

[2] Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli [J].

Bagel, S ;

Hüllen, V ;

Wiedemann, B ;

Heisig, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (04) :868-875

[3] Enhanced levels of λ red-mediated recombinants in mismatch repair mutants [J].

Costantino, N ;

Court, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :15748-15753

[4] A set of recombineering plasmids for gram-negative bacteria [J].

Datta, Simanti ;

Costantino, Nina ;

Court, Donald L. .

GENE, 2006, 379 :109-115

[5] Mechanism of fluoroquinolone action [J].

Drlica, K .

CURRENT OPINION IN MICROBIOLOGY, 1999, 2 (05) :504-508

[6] TOPOISOMERASE POISONS - HARNESSING THE DARK SIDE OF ENZYME MECHANISM [J].

FROELICHAMMON, SJ ;

OSHEROFF, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (37) :21429-21432

[7] Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli [J].

Heisig, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (04) :879-885

[8] Mechanisms of action and resistance of older and newer fluoroquinolones [J].

Hooper, DC .

CLINICAL INFECTIOUS DISEASES, 2000, 31 :S24-S28

[9]

HOOPER DC, 2001, CLIN INFECT DIS S1, V32, P9

[10] TOPOISOMERASE-IV IS A TARGET OF QUINOLONES IN ESCHERICHIA-COLI [J].

KHODURSKY, AB ;

ZECHIEDRICH, EL ;

COZZARELLI, NR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11801-11805

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