Differentiation in microgravity of neural and muscle cells of a vertebrate (amphibian)

被引：14

作者：

Husson, D ^{[1
]}

Gualandris-Parisot, L ^{[1
]}

Foulquier, F ^{[1
]}

Grinfield, S ^{[1
]}

Kan, P ^{[1
]}

Duprat, AM ^{[1
]}

机构：

[1] Univ Toulouse 3, UMR 5547 CNRS, Ctr Dev Biol, INSERM, F-31062 Toulouse, France

来源：

LIFE SCIENCES: SPACE FLIGHT AND THE CENTRAL NERVOUS SYSTEM: THE POTENTIAL INDEPENDENT AND SYNERGISTIC EFFECTS OF MICROGRAVITY AND RADIATION | 1998年 / 22卷 / 02期

关键词：

D O I：

10.1016/S0273-1177(98)80024-0

中图分类号：

V [航空、航天];

学科分类号：

08 ; 0825 ;

摘要：

The CELIMENE space experiment (CELulles en Impesanteur : Muscle Et Neurone Embryonnaires) was devoted to the study of the influence of gravity on the differentiation, the organisation and the maintenance of the highly specialised nervous system and muscular system. CELIMENE was carried out during the first flight of the IBIS hardware (Instrument for BIology in Space) with the fully automatic space mission PHOTON 10 in February 1995. Using the amphibian Pleurodeles waltl as a vertebrate model, in vitro experiments involved immunocytochemical detection of glial-, neuronal- and muscle-specific markers, and neurotransmitters in cells developed under conditions of microgravity compared with Ig controls, on-board and on the ground. We observed that the altered gravity did not disturb cell morphogenesis or differentiation. (C) 1998 COSPAR. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：303 / 308

页数：6

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