The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

被引：21

作者：

Kim, Hak-Jun ^{[1
]}

Kang, Sun-Woong ^{[2
]}

Lim, Hong-Chul ^{[3
]}

Han, Seung-Bum ^{[3
]}

Lee, Jae-Sun ^{[3
]}

Prasad, Leela ^{[3
]}

Kim, Yoon-Jung ^{[4
]}

Kim, Byung-Soo ^{[5
]}

Park, Jung-Ho ^{[3
]}

机构：

[1] Seoul Vet Hosp, Dept Orthoped Surg, Seoul, South Korea

[2] Hanyang Univ, Dept Chem Engn, Seoul, South Korea

[3] Korea Univ, Dept Orthoped Surg, Seoul, South Korea

[4] Seoul Vet Hosp, Dept Pathol, Seoul, South Korea

[5] Hanyang Univ, Dept Chem Engn, Dept Bioengn, Seoul, South Korea

来源：

CONNECTIVE TISSUE RESEARCH | 2007年 / 48卷 / 06期

关键词：

Achilles tendon; fibrin glue; bone morphogenetic protein; bone-tendon junction; transforming growth factor-beta;

D O I：

10.1080/03008200701692610

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-beta and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-beta and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-beta to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

引用

页码：309 / 315

页数：7

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