The proto-oncogene C-KIT maps to canid B-chromosomes

被引：70

作者：

Graphodatsky, AS ^{[1
]}

Kukekova, AV

Yudkin, DV

Trifonov, VA

Vorobieva, NV

Beklemisheva, VR

Perelman, PL

Graphodatskaya, DA

Trut, LN

Yang, FT

Ferguson-Smith, MA

Acland, GM

Aguirre, GD

机构：

[1] SB RAS, Inst Cytol & Genet, Novosibirsk 630090, Russia

[2] Cornell Univ, Coll Vet Med, James A Baker Inst Anim Hlth, Ithaca, NY 14853 USA

[3] Univ Cambridge, Dept Clin Vet Med, Ctr Vet Sci, Cambridge CB3 0ES, England

[4] Univ Penn, Sch Vet Med, Philadelphia, PA 19104 USA

来源：

CHROMOSOME RESEARCH | 2005年 / 13卷 / 02期

关键词：

B-chromosome; Canidae; C-KIT; oncogene;

D O I：

10.1007/s10577-005-7474-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plant and animal karyotypes sometimes contain variable elements, that are referred to as additional or B-chromosomes. It is generally believed that B-chromosomes lack major genes and represent parasitic and selfish elements of a genome. Here we report, for the first time, the localization of a gene to B-chromosomes of mammals: red fox (Vulpes vulpes) and two subspecies of raccoon dog (Nyctereutes procyonoides). Identification of the proto-oncogene C-KIT on B-chromosomes of two Canidae species that diverged from a common ancestor more than 12.5 million years ago argues against the current view of B-chromosomes. Analyses of fox B-chromosomal C-KIT gene from a flow-sorted fox B-chromosome-specific library revealed the presence of intron-exon boundaries and high identity between sequenced regions of canine and fox B-chromosomal C-KIT copies. Identification of C-KIT gene on all B-chromosomes of two canid species provides new insight into the origin and evolution of supernumeraries and their potential role in the genome.

引用

页码：113 / 122

页数：10

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