DNA methylation in metabolic disorders

被引：110

作者：

Barres, Romain ^{[1
]}

Zierath, Juleen R. ^{[2
,3
]}

机构：

[1] Univ New S Wales, Sch Med Sci, Fac Med, Sydney, NSW, Australia

[2] Karolinska Univ Hosp, Sect Integrat Physiol, Dept Mol Med & Surg, Karolinska Inst, Stockholm, Sweden

[3] Karolinska Univ Hosp, Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2011年 / 93卷 / 04期

关键词：

SKELETAL-MUSCLE CELLS; NON-CPG METHYLATION; GENE-EXPRESSION; IN-VITRO; PROMOTER; PPARGC1A; OBESITY; GLUT4; ACID; DIET;

D O I：

10.3945/ajcn.110.001933

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders. Am J Clin Nutr 2011;93(suppl):897S-900S.

引用

页码：897S / 900S

页数：4

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