Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare

被引：40

作者：

Banskota, AH

Tezuka, Y

Phung, LK

Tran, KQ

Saiki, I

Miwa, Y

Taga, T

Kadota, S

机构：

[1] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Toyama 300194, Japan

[2] Hochiminh City Tradit Med Sch, Hochiminh, Vietnam

[3] Natl Univ Hochiminh City, Hochiminh, Vietnam

[4] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(98)00644-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven novel cycloartane-type triterpenes were isolated from Combretum quadrangulare, and their structures were elucidated on the basis of spectral analysis. All these compounds were tested for their cytotoxicity against murine colon 26-L5 carcinoma cells. Methyl quadrangularate B (2) and methyl quadrangularate D (4) exhibited potent cytotoxicity having ED50 values 9.54 and 5.42 mu M, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：3519 / 3524

页数：6

相关论文

共 12 条

[1]

[Anonymous], 1990, MED PLANTS VIETNAM, P119

[2] Chemical constituents of Brazilian propolis and their cytotoxic activities [J].

Banskota, AH ;

Tezuka, Y ;

Prasain, JK ;

Matsushige, K ;

Saiki, I ;

Kadota, S .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (07) :896-900

[3] Hydroperoxycycloartanes from Tillandsia recurvata [J].

Cabrera, GM ;

Seldes, AM .

JOURNAL OF NATURAL PRODUCTS, 1995, 58 (12) :1920-1924

[4] THE STRUCTURES OF NEW LANOSTANE TRITERPENES FROM THE FRUITING BODIES OF HEBELOMA-SENESCENS [J].

GARLASCHELLI, L ;

VIDARI, G ;

VIRTUANI, M ;

VITAFINZI, P ;

MELLERIO, G .

JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (07) :992-1002

[5] CONSTITUENTS OF CIMICIFUGAE RHIZOMA .2. ISOLATION AND STRUCTURES OF NEW CYCLOARTENOL TRITERPENOIDS AND RELATED-COMPOUNDS FROM CIMICIFUGA-FOETIDA L [J].

KADOTA, S ;

LI, JX ;

TANAKA, K ;

NAMBA, T .

TETRAHEDRON, 1995, 51 (04) :1143-1166

[6] TOTAL SYNTHESIS OF NATURAL (-)-PTAQUILOSIN, THE AGLYCON OF A POTENT BRACKEN CARCINOGEN PTAQUILOSIDE, AND THE (+)-ENANTIOMER AND THEIR DNA CLEAVING ACTIVITIES [J].

KIGOSHI, H ;

IMAMURA, Y ;

MIZUTA, K ;

NIWA, H ;

YAMADA, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (08) :3056-3065

[7] JESSIC ACID AND RELATED ACID TRITERPENOIDS FROM COMBRETUM-ELAEAGNOIDES [J].

OSBORNE, R ;

PEGEL, KH .

PHYTOCHEMISTRY, 1984, 23 (03) :635-637

[8]

PASCAL S, 1993, J BIOL CHEM, V268, P11639

[9] THE CHARACTERIZATION OF MOLLIC ACID 3-BETA-D-XYLOSIDE AND ITS GENUINE AGLYCONE MOLLIC ACID, 2 NOVEL 1 ALPHA-HYDROXYCYCLOARTENOIDS FROM COMBRETUM-MOLLE [J].

PEGEL, KH ;

ROGERS, CB .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (08) :1711-1715

[10] ANTINEOPLASTIC AGENTS .291. ISOLATION AND SYNTHESIS OF COMBRETASTATINS A-4, A-5, AND A-6 [J].

PETTIT, GR ;

SINGH, SB ;

BOYD, MR ;

HAMEL, E ;

PETTIT, RK ;

SCHMIDT, JM ;

HOGAN, F .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (10) :1666-1672