C-reactive protein and microalbuminuria differ in their associations with various domains of vascular disease

被引:45
作者
Stuveling, EM
Hillege, HL
Bakker, SJL
Asselbergs, FW
de Jong, PE
Gans, ROB
de Zeeuw, D
机构
[1] Univ Groningen, Dept Clin Pharmacol, NL-9713 AV Groningen, Netherlands
[2] Univ Groningen, Dept Internal Med, NL-9713 AV Groningen, Netherlands
[3] Univ Groningen, Dept Cardiol, NL-9713 AV Groningen, Netherlands
[4] Univ Groningen, Div Nephrol, NL-9713 AV Groningen, Netherlands
关键词
C-reactive protein; urinary albumin excretion; cardiovascular disease; renal function; cardiovascular risk factors;
D O I
10.1016/S0021-9150(03)00252-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
C-reactive protein (CRP) and microalbuminuria (MA) have been identified as risk markers for cardiovascular disease (CVD). We questioned whether CRP and MA are similar markers of vascular disease in different regions of the vascular tree like the heart, kidneys and extremities or if they differ in their relationships with these vascular beds. Baseline levels of CRP and urinary albumin were measured in 6669 non-diabetic participants in the Prevention of Renal and Vascular ENdstage Disease (PREVEND) study, a Dutch cohort derived from the general population. We defined three domains of vascular disease; coronary heart disease (myocardial infarction or infarct pattern on the ECG), renal insufficiency (creatinine clearance < 60 ml min(-1)) and peripheral artery disease (ankle brachial index < 0.9 or lower limb revascularisation). The prevalence of an elevated CRP (27.7 vs. 17.9%) and MA (17.5 vs. 10.4%) were increased in subjects with vascular disease as compared with subjects without CVD. The prevalence of an elevated CRP was equal in subjects with either coronary heart disease, renal insufficiency or peripheral artery disease (28.4 vs. 29.5 vs. 26.0%, NS), whereas MA was most prevalent in subjects with coronary heart disease (22.5 vs. 12.8 vs. 14.9%, P < 0.05). Using multivariate analyses, CRP was independently associated with all three domains of vascular disease, whereas MA was independently associated with coronary heart disease only. In addition, we found synergistic contributions of an elevated CRP and older age to the risk of vascular disease in all three domains. Thus, CRP and MA are risk markers for vascular disease, each showing a different risk profiling for different vascular beds. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:107 / 114
页数:8
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