Repurposing excipients as active inhalation agents: The mannitol story

被引：24

作者：

Anderson, Sandra D. ^{[1
]}

Daviskas, Evangelia ^{[1
,3
]}

Brannan, John D. ^{[1
,4
]}

Chan, Hak Kim ^{[2
]}

机构：

[1] Royal Prince Alfred Hosp, Camperdown, NSW 2050, Australia

[2] Univ Sydney, Pharmaceut Pharmacol & Pharmaceut Sci, Sydney, NSW 2006, Australia

[3] Univ Sydney, Woolcock Inst Med Res, Glebe, NSW 2037, Australia

[4] John Hunter Hosp, Dept Resp & Sleep Med, New Lambton, NSW 2305, Australia

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2018年 / 133卷

关键词：

Mannitol dry powder; Hyperosmolar saline; Asthma; Mucociliary clearance; Cough; Bronchiectasis; Cystic fibrosis; DRY-POWDER MANNITOL; EUCAPNIC VOLUNTARY HYPERVENTILATION; BRONCHIAL PROVOCATION TESTS; SPRAY-DRIED POWDERS; HYPERTONIC SALINE; INHALED MANNITOL; CYSTIC-FIBROSIS; AIRWAY RESPONSIVENESS; MUCOCILIARY CLEARANCE; ASTHMATIC SUBJECTS;

D O I：

10.1016/j.addr.2018.04.003

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The story of how we came to use inhaled mannitol to diagnose asthma and to treat cystic fibrosis began when we were looking for a surrogate for exercise as a stimulus to identify asthma. We had proposed that exercise-induced asthma was caused by an increase in osmolarity of the periciliary fluid. We found hypertonic saline to be a surrogate for exercise but an ultrasonic nebuliser was required. We produced a dry powder of sodium chloride but it proved unstable. We developed a spray dried preparation of mannitol and found that bronchial responsiveness to inhaling mannitol identified people with currently active asthma. We reasoned that mannitol had potential to replace the 'osmotic' benefits of exercise and could be used as a treatment to enhance mucociliary clearance in patients with cystic fibrosis. These discoveries were the start of a journey to develop several registered products that are in clinical use globally today. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：45 / 56

页数：12

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