An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants

被引：392

作者：

Rose, NF

Marx, PA

Luckay, A

Nixon, DF

Moretto, WJ

Donahoe, SM

Montefiori, D

Roberts, A

Buonocore, L

Rose, JK ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA

[3] Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[4] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70043 USA

[5] Gladstone Inst Virol & Immunol, San Francisco, CA 94141 USA

[6] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

来源：

CELL | 2001年 / 106卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(01)00482-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We developed an AIDS vaccine based on attenuated VSV vectors expressing env and gag genes and tested it in rhesus monkeys. Boosting was accomplished using vectors with glycoproteins from different VSV serotypes. Animals were challenged with a pathogenic AIDS virus (SHIV89.6P). Control monkeys showed a severe loss of CD4(+) T cells and high viral loads, and 7/8 progressed to AIDS with an average time of 148 days. All seven vaccinees were initially infected with SHIV89.6P but have remained healthy for up to 14 months after challenge with low or undetectable viral loads. Protection from AIDS was highly significant (p=0.001). VSV vectors are promising candidates for human AIDS vaccine trials because they propagate to high titers and can be delivered without injection.

引用

页码：539 / 549

页数：11

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