FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function

被引:128
作者
Zipfel, PF [1 ]
Skerka, C [1 ]
机构
[1] Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany
来源
IMMUNOLOGY TODAY | 1999年 / 20卷 / 03期
关键词
D O I
10.1016/S0167-5699(98)01432-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A novel regulator of the alternative complement pathway with functions similar to that of factor H has been identified in human plasma. The cDNA encoding this factor H-like protein 1(FHL-1/reconectin) was isolated several years ago. Here, Peter Zipfel and Christine Skerka describe functional analyses revealing that this novel complement regulatory protein forms a molecular link between immune defense and cell adhesion.
引用
收藏
页码:135 / 140
页数:6
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