Diagnostic procedures in the follow-up of patients affected by MEN type 2

被引：2

作者：

Seregni, E

Pallotti, F

Mattavelli, F

Ferrari, L

Martinetti, A

Aliberti, G

Villano, C

Castellani, MR

Bombardieri, E

机构：

[1] Natl Canc Inst, Div Nucl Med, I-20133 Milan, Italy

[2] Natl Canc Inst, Div Head & Neck Surg, I-20133 Milan, Italy

来源：

TUMORI JOURNAL | 2003年 / 89卷 / 05期

关键词：

hyperparathyroidism; medullary thyroid carcinoma (MTC); MEN; 2; syndromes; pheochromocytoma;

D O I：

10.1177/030089160308900524

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple endocrine neoplasia type 2 (MEN 2) is an inherited disease caused by germline mutations in the RET proto-oncogene. The most distinctive MEN 2 variants are MEN 2A, MEN 2B and familial medullary thyroid cancer (FMTC). The hallmark of these syndromes is the development of medullary thyroid carcinoma (MTC), which occurs in almost all patients with MEN 2 syndromes. Other endocrinopathies; are variably expressed. Pheochromocytoma and hyperparathyroidism occur in patients with MEN 2A with a frequency of about 50% and 30%, respectively. In this paper we summarize the most relevant diagnostic methods to detect and monitor MTC, pheochromocytoma and hyperparathyroidism.

引用

页码：563 / 565

页数：3

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