BX471: A CCR1 antagonist with anti-inflammatory activity in man

被引：40

作者：

Horuk, R ^{[1
]}

机构：

[1] Berlex Biosci, Dept Immunol, Richmond, CA 94804 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 09期

关键词：

D O I：

10.2174/1389557054867057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. The chemokine receptor CCR1 appears to be involved in a variety of proinflammatory and autoimmune diseases and this makes it a very attractive therapeutic target. This review discusses the identification, chemistry, biology and therapeutic potential of BX 471 a potent CCR1 antagonist that is currently in the clinic for a variety of indications.

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页码：791 / 804

页数：14

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