Regio- and stereoselective alkylation of 5,5′-bicalix[4]arene.: Access to double calixarenes with different conformations of the two subunits

被引：8

作者：

Bottino, A ^{[1
]}

Cunsolo, F ^{[1
]}

Piattelli, M ^{[1
]}

Neri, P ^{[1
]}

机构：

[1] CNR, Ist Studio Sostanze Nat Interesse Alimentare & Ch, I-95028 Valverde, CT, Italy

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(98)02121-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation of 5,5'-bicalix[4]arene 1, a double calix[4]arene with direct para-para linkage, with PrI or p-tert-butylbenzyl bromide in the presence of various bases has been investigated. Good control of the regio- and stereochemical outcome was obtained, leading to the isolation of tetra-O-alkylated bicalix[4]arene derivatives 3-5 with syn-distal disubstitution at the two subunits and octa-O-alkylated atropisomers in double-cone 2, cone/partial-cone 6-8, double-1,3-alternate 9, and 1,3-alternare/partial-cone 10-12 conformations. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9549 / 9552

页数：4

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