The unfolded protein response and its role in intestinal homeostasis and inflammation

被引：47

作者：

Kaser, Arthur ^{[2
,3
]}

Flak, Magdalena B. ^{[1
]}

Tomczak, Michal F. ^{[1
]}

Blumberg, Richard S. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Gastroenterol Hepatol & Endoscopy Div,Dept Med, Boston, MA 02115 USA

[2] Innsbruck Med Univ, Dept Med 2, Innsbruck, Austria

[3] Univ Cambridge, Addenbrookes Hosp, Dept Med, Div Gastroenterol & Hepatol, Cambridge CB2 2QQ, England

来源：

EXPERIMENTAL CELL RESEARCH | 2011年 / 317卷 / 19期

基金：

欧洲研究理事会; 奥地利科学基金会;

关键词：

Unfolded protein response; Endoplasmic reticulum stress; Inflammatory bowel disease; Intestinal epithelial cells; Paneth cells; ENDOPLASMIC-RETICULUM STRESS; GENOME-WIDE ASSOCIATION; BOWEL-DISEASE; TRANSCRIPTION FACTOR; TRANSGENIC RATS; ER STRESS; MESSENGER-RNA; TRANSMEMBRANE PROTEIN; IMMUNE-RESPONSES; MAMMALIAN-CELLS;

D O I：

10.1016/j.yexcr.2011.07.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The unfolded protein response (UPR) is a signaling pathway from the endoplasmic reticulum (ER) to the nucleus that protects cells from the stress caused by misfolded or unfolded proteins [1, 2]. As such, ER stress is an ongoing challenge for all cells given the central biologic importance of secretion as part of normal physiologic functions. This is especially the case for cells that are highly dependent upon secretory function as part of their major duties. Within mucosal tissues, the intestinal epithelium is especially dependent upon an intact UPR for its normal activities [3]. This review will discuss the UPR and the special role that it provides in the functioning of the intestinal epithelium and, when dysfunctional, its implications for understanding mucosal homeostasis and intestinal inflammation, as occurs in inflammatory bowel disease (IBD). (C) 2011 Elsevier Inc. All rights reserved.

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收藏

页码：2772 / 2779

页数：8

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