Relative contribution of interferon-γ and interleukin-10 to resistance to murine African trypanosomosis

被引:102
作者
Namangala, B [1 ]
Noël, W [1 ]
De Baetselier, P [1 ]
Brys, L [1 ]
Beschin, A [1 ]
机构
[1] Free Univ Brussels VIB, Dept Immunol Parasitol & Ultrastruct, Rhode St Genese, Belgium
关键词
D O I
10.1086/320731
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Resistance to Trypanosoma brucei brucei has been correlated with the ability of infected animals to produce interferon (IFN)-gamma and tumor necrosis factor (TNF) in an early phase of infection, followed by interleukin (IL)-4 and IL-10 in late and chronic stages of the disease. Contributions of IFN-gamma and IL-10 in the control of parasitemia and survival of mice infected with T. brucei brucei were investigated by using IFN-gamma (-/-) and IL-10(-/-) mice. Results suggest that IFN-gamma, mainly secreted by CD8(+) T cells, is essential for parasite control via macrophage activation, which results in TNF and nitric oxide secretions. IL-10, partially secreted by CD4(+) T cells, seems to be important for the survival of infected mice. Its absence resulted in the sustained secretion of inflammatory mediators, which indicated the role of IL-10 in maintaining the balance between pathogenic and protective immune responses during African trypanosomosis.
引用
收藏
页码:1794 / 1800
页数:7
相关论文
共 50 条
[1]   Induction of interferon-gamma, transforming growth factor-beta, and interleukin-4 in mouse strains with different susceptibilities to Trypanosoma brucei brucei [J].
Bakhiet, M ;
Olsson, T ;
Ljungdahl, A ;
Hojeberg, B ;
VanDerMeide, P ;
Kristensson, K .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1996, 16 (06) :427-433
[2]   A TRYPANOSOMA-BRUCEI-BRUCEI-DERIVED FACTOR THAT TRIGGERS CD8+ LYMPHOCYTES TO INTERFERON-GAMMA SECRETION - PURIFICATION, CHARACTERIZATION AND PROTECTIVE EFFECTS INVIVO BY TREATMENT WITH A MONOCLONAL-ANTIBODY AGAINST THE FACTOR [J].
BAKHIET, M ;
OLSSON, T ;
EDLUND, C ;
HOJEBERG, B ;
HOLMBERG, K ;
LORENTZEN, J ;
KRISTENSSON, K .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1993, 37 (02) :165-178
[3]  
BAKHIET M, 1990, CLIN EXP IMMUNOL, V81, P195, DOI 10.1111/j.1365-2249.1990.tb03317.x
[4]  
Bakhiet M, 1996, J IMMUNOL, V157, P3518
[5]   Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms [J].
Beschin, A ;
Brys, L ;
Magez, S ;
Radwanska, M ;
De Baetselier, P .
JOURNAL OF LEUKOCYTE BIOLOGY, 1998, 63 (04) :429-439
[6]   Cellular responses to interferon-gamma [J].
Boehm, U ;
Klamp, T ;
Groot, M ;
Howard, JC .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :749-795
[7]   In vitro simulation of immunosuppression caused by Trypanosoma brucei: Active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression [J].
Darji, A ;
Beschin, A ;
Sileghem, M ;
Heremans, H ;
Brys, L ;
DeBaetselier, P .
INFECTION AND IMMUNITY, 1996, 64 (06) :1937-1943
[8]  
DEGEE ALW, 1985, J IMMUNOL, V134, P2723
[9]  
DEMPSEY WL, 1983, J IMMUNOL, V130, P405
[10]  
FINKELMAN FD, 1990, ANNU REV IMMUNOL, V8, P303, DOI 10.1146/annurev.iy.08.040190.001511