Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

被引：11

作者：

Tagmose, TM

Mogensen, JP

Agerholm, PC

Arkhammar, POG

Wahl, P

Worsaae, A

Hansen, JB

机构：

[1] Novo Nordisk AS, Discovery & Dev, DK-2760 Malov, Denmark

[2] BioImage AS, DK-2860 Soborg, Denmark

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)00297-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3.5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of insulin release from pancreatic beta cells in vitro. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1749 / 1752

页数：4

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