Neurofilament protein levels in CSF are increased in dementia

被引：125

作者：

Rosengren, LE ^{[1
]}

Karlsson, JE

Sjögren, M

Blennow, K

Wallin, A

机构：

[1] Gothenburg Univ, Sahlgrens Univ Hosp, Inst Clin Neurosci, Dept Neurol, S-41345 Gothenburg, Sweden

[2] Gothenburg Univ, Sahlgrens Univ Hosp, Dept Neurochem, Gothenburg, Sweden

[3] Gothenburg Univ, Sahlgrens Univ Hosp, Dept Psychiat, Gothenburg, Sweden

来源：

NEUROLOGY | 1999年 / 52卷 / 05期

关键词：

D O I：

10.1212/WNL.52.5.1090

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light; subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.

引用

页码：1090 / 1093

页数：4

共 10 条

[1] BINSWANGERS DISEASE - A REVIEW
BABIKIAN, V
ROPPER, AH
[J]. STROKE, 1987, 18 (01) : 2 - 12
[2] FRONTAL-LOBE DEGENERATION OF NON-ALZHEIMER TYPE .1. NEUROPATHOLOGY
BRUN, A
[J]. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1987, 6 (03) : 193 - 208
[3] ARTERIOLOSCLEROTIC LEUKOENCEPHALOPATHY IN THE ELDERLY AND ITS RELATION TO WHITE MATTER LESIONS IN BINSWANGERS DISEASE, MULTIINFARCT ENCEPHALOPATHY AND ALZHEIMERS-DISEASE
FERRER, I
BELLA, R
SERRANO, MT
MARTI, E
GUIONNET, N
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1990, 98 (01) : 37 - 50
[4] FRIEDE RL, 1971, J ANAT, V108, P365
[5] QUANTITATIVE AND QUALITATIVE ALTERATIONS OF NEURONAL AND GLIAL INTERMEDIATE FILAMENTS IN RAT NERVOUS-SYSTEM AFTER EXPOSURE TO 2,5-HEXANEDIONE
KARLSSON, JE
ROSENGREN, LE
HAGLID, KG
[J]. JOURNAL OF NEUROCHEMISTRY, 1991, 57 (04) : 1437 - 1444
[6] Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis
Lycke, JN
Karlsson, JE
Andersen, O
Rosengren, LE
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 64 (03) : 402 - 404
[7] Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF
Rosengren, LE
Karlsson, JE
Karlsson, JO
Persson, LI
Wikkelso, C
[J]. JOURNAL OF NEUROCHEMISTRY, 1996, 67 (05) : 2013 - 2018
[8] SOME MORPHOMETRIC ASPECTS OF THE BRAIN IN SENILE DEMENTIA OF THE ALZHEIMER TYPE
TERRY, RD
PECK, A
DETERESA, R
SCHECHTER, R
HOROUPIAN, DS
[J]. ANNALS OF NEUROLOGY, 1981, 10 (02) : 184 - 192
[9] CSF neurofilament and glial fibrillary acidic protein in normal pressure hydrocephalus
Tullberg, M
Rosengren, L
Blomsterwall, E
Karlsson, JE
Wikkelsö, C
[J]. NEUROLOGY, 1998, 50 (04) : 1122 - 1127
[10] Stepwise comparative status analysis (STEP): A tool for identification of regional brain syndromes in dementia
Wallin, A
Edman, A
Blennow, K
Gottfries, CG
Karlsson, I
Regland, B
Sjogren, M
[J]. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 1996, 9 (04) : 185 - 199

← 1 →