The role of chromosomal alterations in human cancer development

被引:25
作者
Gasparini, Patrizia [1 ]
Sozzi, Gabriella [1 ]
Pierotti, Marco A. [1 ]
机构
[1] Fdn IRCCS, Inst Nazl Tumori, Cytogenet & Mol Cytogenet Dept, I-20133 Milan, Italy
关键词
chromosomal rearrangements; fusion genes; fragile site; genomic instability; double strand break; gene deregulation;
D O I
10.1002/jcb.21481
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cancer cells become unstable and compromised because several cancer-predisposing mutations affect genes that are responsible for maintaining the genomic instability. Several factors influence the formation of chromosomal rearrangements and consequently of fusion genes and their role in tumorigenesis. Studies over the past decades have revealed that recurring chromosome rearrangements leading to fusion genes have a biological and clinical impact not only on leukemias and lymphomas, but also on certain epithelial tumors. With the implementation of new and powerful cytogenetic and molecular techniques the identification of fusion genes in solid tumors is being facilitated. Overall, the study of chromosomal translocations have revealed several recurring themes, and reached important insights into the process of malignant transformation. However, the mechanisms behind these translocations remain unclear. A more thorough understanding of the mechanisms that cause translocations will be aided by continuing characterization of translocation breakpoints and by developing in vitro and in vivo model systems that can generate chromosome translocation.
引用
收藏
页码:320 / 331
页数:12
相关论文
共 36 条
[1]   DNA double-strand break repair and chromosome translocations [J].
Agarwal, Sheba ;
Tafel, Agnieszka A. ;
Kanaar, Roland .
DNA REPAIR, 2006, 5 (9-10) :1075-1081
[2]   Fusion genes in solid tumors [J].
Åman, P .
SEMINARS IN CANCER BIOLOGY, 1999, 9 (04) :303-318
[3]  
Åman P, 2005, SEMIN CANCER BIOL, V15, P236, DOI 10.1016/j.semcancer.2005.01.009
[4]   Causes of oncogenic chromosomal translocation [J].
Aplan, PD .
TRENDS IN GENETICS, 2006, 22 (01) :46-55
[5]   Common fragile sites as targets for chromosome rearrangements [J].
Arlt, Martin F. ;
Durkin, Sandra G. ;
Ragland, Ryan L. ;
Glover, Thomas W. .
DNA REPAIR, 2006, 5 (9-10) :1126-1135
[6]   Cancer genetics: from Boveri and Mendel to microarrays [J].
Balmain, A .
NATURE REVIEWS CANCER, 2001, 1 (01) :77-82
[7]  
Bednarek AK, 2000, CANCER RES, V60, P2140
[8]   THE MOLECULAR-GENETICS OF CANCER [J].
BISHOP, JM .
SCIENCE, 1987, 235 (4786) :305-311
[9]  
BONGARZONE I, 1994, CANCER RES, V54, P2979
[10]   Analysis of DNA double-strand break repair pathways in mice [J].
Brugmans, Linda ;
Kanaar, Roland ;
Essers, Jeroen .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2007, 614 (1-2) :95-108