Disease association, origin, and clinical relevance of autoantibodies to the glycolytic enzyme enolase

被引:57
作者
Gitlits, VM [1 ]
Toh, BH [1 ]
Sentry, JW [1 ]
机构
[1] Monash Univ, Sch Med, Dept Pathol & Immunol, Prahran, Vic 3181, Australia
关键词
glycolytic enzyme; enolase; autoimmunity; autoantibodies;
D O I
10.2310/6650.2001.34040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Serum autoantibodies to the glycolytic enzyme enolase have been reported in a diverse range of inflammatory, degenerative, and psychiatric disorders. Diseases in which these antibodies have been reported in high incidence include autoimmune polyglandular syndrome type 1 (80%, 35 of 44), primary (69%, 60 of 87), and secondary (58%, 14 of 24) membranous nephropathy, cancer-associated retinopathy (68.8%, 11 of 16), autoimmune hepatitis type 1 (60%, 12 of 20), mixed cryoglobulinemia with renal involvement (63.6%, seven of 11), cystoid macular edema (60%, six of 10), and endometriosis (50%, 21 of 41). In autoimmune polyglandular syndrome type 1 patients, all had chronic mucocutaneous candidiasis with demonstrated antibody reactivity to candida enolase, which is suggestive of cross reactivity or epitope mimicry. Formation of autoantibodies to enolase may be a normal process, with reported incidence in apparently healthy subjects ranging from 0% (zero of 91) to 11.7% (seven of 60). Nonetheless, we suggest that excessive production of these autoantibodies, which are generated as a consequence of uptake of enolase by antigen-presenting cells and subsequent B cell activation, can potentially initiate tissue injury as a result of immune complex deposition.
引用
收藏
页码:138 / 145
页数:8
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