Langerhans cells in the neuro-immuno-cutaneous system

被引：31

作者：

Misery, L ^{[1
]}

机构：

[1] Hop Edouard Herriot, Dept Dermatol, INSERM U346 Human Skin & Immun, F-69437 Lyon, France

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 89卷 / 1-2期

关键词：

Langerhans cell; PGP9.5; substance P; CGRP; GRP; MSH;

D O I：

10.1016/S0165-5728(98)00117-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Langerhans cells are epidermal antigen presenting cells. They are able to express some neuronal markers. They express many neuropeptide receptors. Neuropeptides are able to modulate Langerhans cell functions. Langerhans cells are closely connected with nerve fibers in the epidermis. Thus, Langerhans cells and the nervous system are anatomically and functionnaly associated. We suggest that they belong to a neuroimmunocutaneous system. The interactions between nervous and immune system are probably important in the pathophysiogeny of inflammatory dermatoses. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：83 / 87

页数：5

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