Macrophages recognize streptococci through bacterial single-stranded RNA

被引：57

作者：

Deshmukh, Sachin D. ^{[1
]}

Kremer, Bernhard ^{[1
]}

Freudenberg, Marina ^{[2
]}

Bauer, Stefan ^{[3
]}

Golenbock, Douglas T. ^{[4
]}

Henneke, Philipp ^{[1
,5
]}

机构：

[1] Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany

[2] Max Planck Inst Immunobiol, D-79108 Freiburg, Germany

[3] Univ Marburg, BMFZ, Inst Immunol, D-35043 Marburg, Germany

[4] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA

[5] Univ Freiburg, Med Ctr, Ctr Paediat & Adolescent Med, D-79106 Freiburg, Germany

来源：

EMBO REPORTS | 2011年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

bacterial infection; RNA; phagocytosis; signal transduction; GROUP-B STREPTOCOCCUS; TOLL-LIKE RECEPTORS; VACCINIA VIRAL-DNA; DENDRITIC CELLS; STAPHYLOCOCCUS-AUREUS; INNATE IMMUNITY; TLR2; ACTIVATION; PATHOGEN; ACID;

D O I：

10.1038/embor.2010.189

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Group B streptococcus (GBS) is a leading cause of both neonatal sepsis and meningitis, two diseases that are characterized by inflammation. However, the manner in which GBS organisms are recognized by monocytes and macrophages is poorly understood. In this study, we report that the recognition of GBS and other Gram-positive bacteria by macrophages and monocytes relies on bacterial single-stranded RNA (ssRNA). ssRNA interacts with a signalling complex, which comprises the Toll-like receptor adaptors MyD88 and UNC-93B, but not the established MyD88-dependent ssRNA sensors. The role of ssRNA in the recognition of Gram-positive bacteria-leading to the induction of inflammatory cytokines-has potential implications for sepsis pathogenesis, diagnosis and treatment.

引用

页码：71 / 76

页数：6

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