The new immunosuppression: just kill the T cell

被引：11

作者：

Waldmann, H ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

NATURE MEDICINE | 2003年 / 9卷 / 10期

关键词：

D O I：

10.1038/nm1003-1259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibodies to the CD40 ligand have modulated the immune system in animal experiments and in human clinical trials. Assumptions about how these antibodies work are now reexamined.

引用

页码：1259 / 1260

页数：2

共 10 条

[1] ACTIVELY ACQUIRED TOLERANCE OF FOREIGN CELLS [J].

BILLINGHAM, RE ;

BRENT, L ;

MEDAWAR, PB .

NATURE, 1953, 172 (4379) :603-606

[2] Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning [J].

Durham, MM ;

Bingaman, AW ;

Adams, AB ;

Ha, JW ;

Waitze, SY ;

Pearson, TC ;

Larsen, CP .

JOURNAL OF IMMUNOLOGY, 2000, 165 (01) :1-4

[3] Cutting edge: Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance [J].

Graca, L ;

Honey, K ;

Adams, E ;

Cobbold, SP ;

Waldmann, H .

JOURNAL OF IMMUNOLOGY, 2000, 165 (09) :4783-4786

[4] Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged craft survival in a CTLA4-dependent manner [J].

Iwakoshi, NN ;

Mordes, JP ;

Markees, TG ;

Phillips, NE ;

Rossini, AA ;

Greiner, DL .

JOURNAL OF IMMUNOLOGY, 2000, 164 (01) :512-521

[5]

Kawai T, 2000, NAT MED, V6, P114, DOI 10.1038/72162

[6] Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates [J].

Kirk, AD ;

Burkly, LC ;

Batty, DS ;

Baumgartner, RE ;

Berning, JD ;

Buchanan, K ;

Fechner, JH ;

Germond, RL ;

Kampen, RL ;

Patterson, NB ;

Swanson, SJ ;

Tadaki, DK ;

TenHoor, CN ;

White, L ;

Knechtle, SJ ;

Harlan, DM .

NATURE MEDICINE, 1999, 5 (06) :686-693

[7] Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways [J].

Larsen, CP ;

Elwood, ET ;

Alexander, DZ ;

Ritchie, SC ;

Hendrix, R ;

TuckerBurden, C ;

Cho, HR ;

Aruffo, A ;

Hollenbaugh, D ;

Linsley, PS ;

Winn, KJ ;

Pearson, TC .

NATURE, 1996, 381 (6581) :434-438

[8] Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade [J].

Monk, NJ ;

Hargreaves, REG ;

Marsh, JE ;

Farrar, CA ;

Sacks, SH ;

Millrain, M ;

Simpson, E ;

Dyson, J ;

Jurcevic, S .

NATURE MEDICINE, 2003, 9 (10) :1275-1280

[9] INDUCTION OF CLASSICAL TRANSPLANTATION TOLERANCE IN THE ADULT [J].

QIN, SX ;

COBBOLD, S ;

BENJAMIN, R ;

WALDMANN, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (03) :779-794

[10] Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance [J].

Wells, AD ;

Li, XC ;

Li, YS ;

Walsh, MC ;

Zheng, XX ;

Wu, ZH ;

Nuñez, G ;

Tang, AM ;

Sayegh, M ;

Hancock, WW ;

Strom, TB ;

Turka, LA .

NATURE MEDICINE, 1999, 5 (11) :1303-1307

← 1 →