Endocrine immune interactions in human parturition

被引：78

作者：

Golightly, E. ^{[1
]}

Jabbour, H. N. ^{[2
]}

Norman, J. E. ^{[1
]}

机构：

[1] Univ Edinburgh, Div Reprod & Dev Sci, Ctr Reprod Biol, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Reprod Biol, MRC, Human Reprod Sci Unit,Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 335卷 / 01期

基金：

英国医学研究理事会;

关键词：

Parturition; Endocrine; Inflammation; Immune; CORTICOTROPIN-RELEASING HORMONE; FACTOR-KAPPA-B; HUMAN FETAL MEMBRANES; PLATELET-ACTIVATING-FACTOR; INDUCED PRETERM BIRTH; OXYTOCIN RECEPTOR; HUMAN MYOMETRIUM; PROINFLAMMATORY CYTOKINES; INTERLEUKIN-8; EXPRESSION; PROGESTERONE WITHDRAWAL;

D O I：

10.1016/j.mce.2010.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human parturition is an inflammatory event, modulated and influenced by a host of other environmental and physiological processes, including the endocrine hormones. Complex bidirectional communication occurs between the two systems to bring about some of the changes that are seen in labour, an event that is not yet fully understood. Preterm birth is a major problem in obstetrics and neonatology, with dysfunctional labour or prolonged pregnancy also making increasingly significant contributions to maternal morbidity. With better understanding of normal and abnormal parturition we may be able to develop novel ways of treating these complications of pregnancy and reduce maternal and neonatal morbidity and mortality. This review discusses the crucial role that endocrine-immune interaction plays in the process of labour and in the processes of abnormal and preterm labour. We propose that amongst these complex interactions it is the immune system that is the driving force behind human parturition. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 59

页数：8

共 107 条

[1] Human labour is associated with nuclear factor-κB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal' [J].