The role of nitric oxide in radiation nephropathy

被引:22
作者
Cohen, EP
Fish, BL
Moulder, JE
机构
[1] MED COLL WISCONSIN,DEPT MED,MILWAUKEE,WI 53226
[2] MED COLL WISCONSIN,DEPT RADIAT ONCOL,MILWAUKEE,WI 53226
关键词
radiation; kidney; hypertension; nitric oxide; cGMP; rat;
D O I
10.1076/apab.104.2.200.12880
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sufficient radiation will cause kidney injury with hypertension, azotemia, and death from renal failure. There is early endothelial injury after radiation, which could lead to a deficit of constitutive nitric oxide (NO) synthesis, with capillary thrombosis and hypertension, both of which are seen in radiation nephropathy. In a rat radiation nephropathy model, the serial evolution of urinary cyclic guanosine monophosphate (cGMP), a marker of kidney NO, was studied and a deficit in urinary cGMP was found. This radiation-induced cGMP deficit was prevented by high-dose Captopril treatment Low-dose Captopril treatment protected against radiation nephropathy without preventing the decrease in urinary cGMP. An inhibitor of NO synthesis, L-N-arginine-methylester, did not blunt the beneficial effect of Captopril treatment. We conclude that there is a deficit in urinary cGMP in radiation nephropathy, but that prevention of this deficit is not essential in the prevention of radiation nephropathy by Captopril.
引用
收藏
页码:200 / 206
页数:7
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