A central role for S-nitrosylation in apoptosis

被引：96

作者：

Benhar, M ^{[1
]}

Stamler, JS ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 07期

关键词：

D O I：

10.1038/ncb0705-645

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

New work reveals a key signal transduction pathway through which nitric oxide ( NO) regulates apoptosis induced by disparate cellular stresses. Glyceraldehyde- 3- phosphate dehydrogenase ( GAPDH) is S- nitrosylated by NO, which initiates an interaction with the E3 ligase Siah1, leading to nuclear translocation and ubiquitin- mediated degradation of nuclear target proteins.

引用

页码：645 / 646

页数：2

共 15 条

[1] Glyceraldehyde-3-phosphate dehydrogenase, apoptosis and neurodegenerative diseases
Chuang, DM
Hough, C
Senatorov, VV
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2005, 45 : 269 - +
[2] NITRIC-OXIDE MEDIATES GLUTAMATE NEUROTOXICITY IN PRIMARY CORTICAL CULTURES
DAWSON, VL
DAWSON, TM
LONDON, ED
BREDT, DS
SNYDER, SH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) : 6368 - 6371
[3] An apoptotic model for nitrosative stress
Eu, JP
Liu, LM
Zeng, M
Stamler, JS
[J]. BIOCHEMISTRY, 2000, 39 (05) : 1040 - 1047
[4] A central role for S-nitrosothiols in plant disease resistance
Feechan, A
Kwon, E
Yun, BW
Wang, YQ
Pallas, JA
Loake, GJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (22) : 8054 - 8059
[5] S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Hara, MR
Agrawal, N
Kim, SF
Cascio, MB
Fujimuro, M
Ozeki, Y
Takahashi, M
Cheah, JH
Tankou, SK
Hester, LD
Ferris, CD
Hayward, SD
Snyder, SH
Sawa, A
[J]. NATURE CELL BIOLOGY, 2005, 7 (07) : 665 - U40
[6] Protein S-nitrosylation:: Purview and parameters
Hess, DT
Matsumoto, A
Kim, SO
Marshall, HE
Stamler, JS
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (02) : 150 - 166
[7] NITRIC-OXIDE - A CYTO-TOXIC ACTIVATED MACROPHAGE EFFECTOR MOLECULE
HIBBS, JB
TAINTOR, RR
VAVRIN, Z
RACHLIN, EM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (01) : 87 - 94
[8] ISCHIROPOULOS H, 1992, ARCH BIOCHEM BIOPHYS, V298, P451
[9] A REDOX-BASED MECHANISM FOR THE NEUROPROTECTIVE AND NEURODESTRUCTIVE EFFECTS OF NITRIC-OXIDE AND RELATED NITROSO-COMPOUNDS
LIPTON, SA
CHOI, YB
PAN, ZH
LEI, SZZ
CHEN, HSV
SUCHER, NJ
LOSCALZO, J
SINGEL, DJ
STAMLER, JS
[J]. NATURE, 1993, 364 (6438) : 626 - 632
[10] Essential roles of S-nitrosothiols in vascular horneostasis and endotoxic shock
Liu, L
Yan, Y
Zeng, M
Zhang, J
Hanes, MA
Ahearn, G
McMahon, TJ
Dickfeld, T
Marshall, HE
Que, LG
Stamler, JS
[J]. CELL, 2004, 116 (04) : 617 - 628

← 1 2 →