Arousal mechanisms: Speedy flies don't sleep at night

被引:18
作者
Birman, S [1 ]
机构
[1] Univ Mediterrannee, IBDM, Inst Dev Biol, CNRS INSERM, F-13288 Marseille, France
关键词
D O I
10.1016/j.cub.2005.06.032
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alertness and behavioral performance depend on an animal's level of arousal. In vertebrates, reinforcement and maintenance of arousal in the cortex are ensured by diffuse inputs from neurons releasing biogenic amine neuromodulators. Fruit flies similarly use dopamine for arousal control, indicating an ancient evolutionary origin of this essential feature of the functioning brain.
引用
收藏
页码:R511 / R513
页数:3
相关论文
共 19 条
[1]   What keeps us awake: The neuropharmacology of stimulants and wakefulness promoting medications [J].
Boutrel, B ;
Koob, GF .
SLEEP, 2004, 27 (06) :1181-1194
[2]   D-amphetamine remediates attentional performance in rats with dorsal prefrontal lesions [J].
Chudasama, Y ;
Nathwani, F ;
Robbins, TW .
BEHAVIOURAL BRAIN RESEARCH, 2005, 158 (01) :97-107
[3]   Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex [J].
Chudasama, Y ;
Robbins, TW .
NEUROPSYCHOPHARMACOLOGY, 2004, 29 (09) :1628-1636
[4]   Reduced sleep in Drosophila shaker mutants [J].
Cirelli, C ;
Bushey, D ;
Hill, S ;
Huber, R ;
Kreber, R ;
Ganetzky, B ;
Tononi, G .
NATURE, 2005, 434 (7037) :1087-1092
[5]   Cognitive consonance: complex brain functions in the fruit fly and its relatives [J].
Greenspan, RJ ;
van Swinderen, B .
TRENDS IN NEUROSCIENCES, 2004, 27 (12) :707-711
[6]   DRIVES AND THE CNS (CONCEPTUAL NERVOUS SYSTEM) [J].
HEBB, DO .
PSYCHOLOGICAL REVIEW, 1955, 62 (04) :243-254
[7]   Rest in Drosophila is a sleep-like state [J].
Hendricks, JC ;
Finn, SM ;
Panckeri, KA ;
Chavkin, J ;
Williams, JA ;
Sehgal, A ;
Pack, AI .
NEURON, 2000, 25 (01) :129-138
[8]   Modafinil maintains waking in the fruit fly drosophila melanogaster [J].
Hendricks, JC ;
Kirk, D ;
Panckeri, K ;
Miller, MS ;
Pack, AI .
SLEEP, 2003, 26 (02) :139-146
[9]   Drosophila melanogaster:: An insect model for fundamental studies of sleep [J].
Ho, KS ;
Sehgal, A .
CIRCADIAN RHYTHMS, 2005, 393 :772-793
[10]   Sleep homeostasis in Drosophila melanogaster [J].
Huber, R ;
Hill, SL ;
Holladay, C ;
Biesiadecki, M ;
Tononi, G ;
Cirelli, C .
SLEEP, 2004, 27 (04) :628-639