NONCODEV5: a comprehensive annotation database for long non-coding RNAs

被引：437

作者：

Fang, ShuangSang ^{[1
,2
]}

Zhang, LiLi ^{[2
,3
]}

Guo, JinCheng ^{[1
,4
]}

Niu, YiWei ^{[2
,3
]}

Wu, Yang ^{[1
]}

Li, Hui ^{[1
]}

Zhao, Lian He ^{[1
,2
]}

Li, Xi Yuan ^{[1
]}

Teng, Xue Yi ^{[2
,3
]}

Sun, XianHui ^{[2
,3
]}

Sun, Liang ^{[1
]}

Zhang, Michael Q. ^{[5
]}

Chen, RunSheng ^{[3
]}

Zhao, Yi ^{[1
,6
]}

机构：

[1] Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Inst Biophys, CAS Key Lab RNA Biol, Beijing 100101, Peoples R China

[4] Shantou Univ, Med Coll, Dept Biochem & Mol Biol, Shantou 515041, Peoples R China

[5] Tsinghua Univ, Sch Med, Ctr Synthet & Syst Biol,TNLIST Dept Automat, MOE Key Lab Bioinformat & Bioinformat Div, Beijing 100084, Peoples R China

[6] Chinese Acad Sci, Inst Comp Technol, LuoYang Branch, Luoyang, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2018年 / 46卷 / D1期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

GENOME-WIDE ASSOCIATION; MANUALLY CURATED DATABASE; SECONDARY STRUCTURE; MOLECULAR-MECHANISMS; PROBING DATA; CANCER; DISEASE; RESOURCE; EXOSOMES; FEATURES;

D O I：

10.1093/nar/gkx1107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

NONCODE (http://www.bioinfo.org/noncode) is a systematic database that is dedicated to presenting the most complete collection and annotation of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs). Since NONCODE 2016 was released two years ago, the amount of novel identified ncRNAs has been enlarged by the reduced cost of next-generation sequencing, which has produced an explosion of newly identified data. The third-generation sequencing revolution has also offered longer and more accurate annotations. Moreover, accumulating evidence confirmed by biological experiments has provided more comprehensive knowledge of lncRNA functions. The ncRNA data set was expanded by collecting newly identified ncRNAs from literature published over the past two years and integration of the latest versions of RefSeq and Ensembl. Additionally, pig was included in the database for the first time, bringing the total number of species to 17. The number of lncRNAs in NONCODEv5 increased from 527 336 to 548 640. NONCODEv5 also introduced three important new features: (i) human lncRNA-disease relationships and single nucleotide polymorphism-lncRNA-disease relationships were constructed; (ii) human exosome lncRNA expression profiles were displayed; (iii) the RNA secondary structures of NONCODE human transcripts were predicted. NONCODEv5 is also accessible through http://www.noncode.org/.

引用

页码：D308 / D314

页数：7

共 67 条

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