Detection of aspirin resistance by PFA-100: Prevalence and aspirin compliance in patients with chronic stable angina

被引：13

作者：

Crowe, B ^{[1
]}

Abbas, S ^{[1
]}

Meany, B ^{[1
]}

de Haan, J ^{[1
]}

Cahill, MR ^{[1
]}

机构：

[1] Mid Western Reg Hosp, Dept Cardiol, Dept Hematol, Limerick, Ireland

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2005年 / 31卷 / 04期

关键词：

platelets; platelet activation; PFA-100; nitrates; aspirin resistance; salicylate levels;

D O I：

10.1055/s-2005-916677

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Most acute coronary syndromes result from a platelet-rich occlusion of the coronary arteries. Antiplatelet drugs are of proven efficacy in preventing myocardial infarction, unstable angina, and stroke. However, not all patients on aspirin (ASA) benefit. We studied the phenomenon of aspirin resistance with a simple and reliable platelet function analyzer-the PFA-100. Studying 31 patients with unstable angina and 105 controls, we found aspirin resistance in 42% of patients, most of whom were shown to be compliant utilizing concomitant salicylate levels.

引用

页码：420 / 425

页数：6

共 36 条

[1]

[Anonymous], 1988, BRIT MED J, V296, P320

[2]

Baigent C, 2002, BMJ-BRIT MED J, V324, P71, DOI 10.1136/bmj.324.7329.71

[3]

Böck M, 1999, BRIT J HAEMATOL, V106, P898

[4]

BUCHANAN MR, 1995, CAN J CARDIOL, V11, P221

[5] EFFECTS OF AGE, SEX AND THE ORAL-CONTRACEPTIVE ON THE PLATELET MEMBRANE FIBRINOGEN BINDING-SITE (GLYCOPROTEIN-IIB GLYCOPROTEIN-IIIA) [J].

CAHILL, M ;

MISTRY, R ;

CHAPMAN, C ;

WOOD, JK ;

BARNETT, DB .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 33 (01) :11-15

[6] PREVENTION OF RESTENOSIS AFTER ANGIOPLASTY [J].

CAHILL, MR ;

MACEY, MG ;

DAWSON, JR ;

NEWLAND, AC .

LANCET, 1994, 343 (8909) :1361-1361

[7] FIXATION WITH FORMALDEHYDE INDUCES EXPRESSION OF ACTIVATION-DEPENDENT PLATELET MEMBRANE-GLYCOPROTEINS, P-SELECTIN (CD62) AND GP53 (CD63) [J].

CAHILL, MR ;

MACEY, MG ;

NEWLAND, AC .

BRITISH JOURNAL OF HAEMATOLOGY, 1993, 84 (03) :527-529

[8] ASPIRIN, SULFINPYRAZONE, OR BOTH IN UNSTABLE ANGINA - RESULTS OF A CANADIAN MULTICENTER TRIAL [J].

CAIRNS, JA ;

GENT, M ;

SINGER, J ;

FINNIE, KJ ;

FROGGATT, GM ;

HOLDER, DA ;

JABLONSKY, G ;

KOSTUK, WJ ;

MELENDEZ, LJ ;

MYERS, MG ;

SACKETT, DL ;

SEALEY, BJ ;

TANSER, PH .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (22) :1369-1375

[9]

Cattaneo M, 1999, THROMB HAEMOSTASIS, V82, P35

[10] PLATELET-RELEASE AND THROMBOXANE SYNTHESIS IN SYMPTOMATIC CORONARY-ARTERY DISEASE [J].

DEBOER, AC ;

TURPIE, AGG ;

BUTT, RW ;

JOHNSTON, RV ;

GENTON, E .

CIRCULATION, 1982, 66 (02) :327-333

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