Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

被引：59

作者：

Dereli-Oez, Ayguel ^{[1
]}

Versini, Gwennaelle ^{[1
]}

Halazonetis, Thanos D. ^{[1
,2
]}

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1205 Geneva, Switzerland

[2] Univ Geneva, Dept Biochem, CH-1205 Geneva, Switzerland

来源：

MOLECULAR ONCOLOGY | 2011年 / 5卷 / 04期

关键词：

Genomic deletions; Copy number changes; DNA replication stress; Common fragile sites; Large genes; TUMOR-SUPPRESSOR GENE; COMMON FRAGILE SITES; ONCOGENE-INDUCED SENESCENCE; COLORECTAL CANCERS; DAMAGE RESPONSE; INSTABILITY; MICE; MUTATIONS; TUMORIGENESIS; CHROMOSOMES;

D O I：

10.1016/j.molonc.2011.05.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human cancers are characterized by the presence of genomic instability. Recently, two studies have catalogued the presence of a specific class of genomic aberrations, large deletions and insertions, in a few thousand human cancers and reported that most of the prevalent recurrent focal deletions targeted common fragile sites and large genes. In various experimental systems, deletions in common fragile sites and large genes have been linked to the presence of DNA replication stress. Thus, taken together, these results suggest the presence of DNA replication stress in human cancers, consistent with the recently proposed oncogene-induced DNA damage model for cancer development. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：308 / 314

页数：7

共 52 条

[1] Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors [J].

Al-Tassan, N ;

Chmiel, NH ;

Maynard, J ;

Fleming, N ;

Livingston, AL ;

Williams, GT ;

Hodges, AK ;

Davies, DR ;

David, SS ;

Sampson, JR ;

Cheadle, JR .

NATURE GENETICS, 2002, 30 (02) :227-232

[2] Targeted deletion of Wwox reveals a tumor suppressor function [J].

Aqeilan, Rami I. ;

Trapasso, Francesco ;

Hussain, Sadiq ;

Costinean, Stefan ;

Marshall, Dean ;

Pekarsky, Yuri ;

Hagan, John P. ;

Zanesi, Nicola ;

Kaou, Mohamed ;

Steint, Gary S. ;

Lian, Jane B. ;

Croce, Carlo M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (10) :3949-3954

[3] Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants [J].

Arlt, Martin F. ;

Mulle, Jennifer G. ;

Schaibley, Valerie M. ;

Ragland, Ryan L. ;

Durkin, Sandra G. ;

Warren, Stephen T. ;

Glover, Thomas W. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 84 (03) :339-350

[4] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis [J].

Bartkova, J ;

Horejsi, Z ;

Koed, K ;

Krämer, A ;

Tort, F ;

Zieger, K ;

Guldberg, P ;

Sehested, M ;

Nesland, JM ;

Lukas, C ;

Orntoft, T ;

Lukas, J ;

Bartek, J .

NATURE, 2005, 434 (7035) :864-870

[5] Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints [J].

Bartkova, Jirina ;

Rezaei, Nousin ;

Liontos, Michalis ;

Karakaidos, Panagiotis ;

Kletsas, Dimitris ;

Issaeva, Natalia ;

Vassiliou, Leandros-Vassilios F. ;

Kolettas, Evangelos ;

Niforou, Katerina ;

Zoumpourlis, Vassilis C. ;

Takaoka, Munenori ;

Nakagawa, Hiroshi ;

Tort, Frederic ;

Fugger, Kasper ;

Johansson, Fredrik ;

Sehested, Maxwell ;

Andersen, Claus L. ;

Dyrskjot, Lars ;

Orntoft, Torben ;

Lukas, Jiri ;

Kittas, Christos ;

Helleday, Thomas ;

Halazonetis, Thanos D. ;

Bartek, Jiri ;

Gorgoulis, Vassilis G. .

NATURE, 2006, 444 (7119) :633-637

[6] The landscape of somatic copy-number alteration across human cancers [J].

Beroukhim, Rameen ;

Mermel, Craig H. ;

Porter, Dale ;

Wei, Guo ;

Raychaudhuri, Soumya ;

Donovan, Jerry ;

Barretina, Jordi ;

Boehm, Jesse S. ;

Dobson, Jennifer ;

Urashima, Mitsuyoshi ;

Mc Henry, Kevin T. ;

Pinchback, Reid M. ;

Ligon, Azra H. ;

Cho, Yoon-Jae ;

Haery, Leila ;

Greulich, Heidi ;

Reich, Michael ;

Winckler, Wendy ;

Lawrence, Michael S. ;

Weir, Barbara A. ;

Tanaka, Kumiko E. ;

Chiang, Derek Y. ;

Bass, Adam J. ;

Loo, Alice ;

Hoffman, Carter ;

Prensner, John ;

Liefeld, Ted ;

Gao, Qing ;

Yecies, Derek ;

Signoretti, Sabina ;

Maher, Elizabeth ;

Kaye, Frederic J. ;

Sasaki, Hidefumi ;

Tepper, Joel E. ;

Fletcher, Jonathan A. ;

Tabernero, Josep ;

Baselga, Jose ;

Tsao, Ming-Sound ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Janne, Pasi A. ;

Daly, Mark J. ;

Nucera, Carmelo ;

Levine, Ross L. ;

Ebert, Benjamin L. ;

Gabriel, Stacey ;

Rustgi, Anil K. ;

Antonescu, Cristina R. ;

Ladanyi, Marc ;

Letai, Anthony .

NATURE, 2010, 463 (7283) :899-905

[7] Signatures of mutation and selection in the cancer genome [J].

Bignell, Graham R. ;

Greenman, Chris D. ;

Davies, Helen ;

Butler, Adam P. ;

Edkins, Sarah ;

Andrews, Jenny M. ;

Buck, Gemma ;

Chen, Lina ;

Beare, David ;

Latimer, Calli ;

Widaa, Sara ;

Hinton, Jonathon ;

Fahey, Ciara ;

Fu, Beiyuan ;

Swamy, Sajani ;

Dalgliesh, Gillian L. ;

Teh, Bin T. ;

Deloukas, Panos ;

Yang, Fengtang ;

Campbell, Peter J. ;

Futreal, P. Andrew ;

Stratton, Michael R. .

NATURE, 2010, 463 (7283) :893-U61

[8] Hotspots of Large Rare Deletions in the Human Genome [J].

Bradley, W. Edward C. ;

Raelson, John V. ;

Dubois, Daniel Y. ;

Godin, Eric ;

Fournier, Helene ;

Prive, Charles ;

Allard, Rene ;

Pinchuk, Vadym ;

Lapalme, Micheline ;

Paulussen, Rene J. A. ;

Belouchi, Abdelmajid .

PLOS ONE, 2010, 5 (02)

[9] Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments [J].

Catania, Elizabeth Haldeman ;

Pimenta, Aurea ;

Levitt, Pat .

BEHAVIOURAL BRAIN RESEARCH, 2008, 188 (02) :380-390

[10] Cancer in xeroderma pigmentosum and related disorders of DNA repair [J].

Cleaver, JE .

NATURE REVIEWS CANCER, 2005, 5 (07) :564-573

← 1 2 3 4 5 6 →