Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus

被引：23

作者：

Albright, CD

Mar, MH

Craciunescu, CN

Song, JN

Zeisel, SH

机构：

[1] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2005年 / 159卷 / 02期

关键词：

brain development; chemoattraction; choline; hippocampus; pregnancy;

D O I：

10.1016/j.devbrainres.2005.07.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alterations in maternal dietary choline availability during days 12-17 of pregnancy led to an increase in the level of immunoreactive netrin-1 and a decrease in the level of DCC protein in the developing fetal mouse brain hippocampus compared with controls. Changes in the expression of cell migration cues during development could account for some of the lifelong consequences of maternal dietary choline availability for cognitive and memory processes. (c) 2005 Elsevier B.V. All rights reserved.

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收藏

页码：149 / 154

页数：6

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