ent-Kaurane Diterpenoids from Croton tonkinensis Stimulate Osteoblast Differentiation

被引：28

作者：

Dao, Trong-Tuan ^{[1
]}

Lee, Kwang-Youl ^{[2
]}

Jeong, Hyung-Min ^{[2
]}

Nguyen, Phi-Hung ^{[1
]}

Tran, Tien Lam ^{[1
]}

Thuong, Phuong-Thien ^{[3
]}

Nguyen, Bich-Thu ^{[3
]}

Oh, Won-Keun ^{[1
]}

机构：

[1] Chosun Univ, Project Team BK21, Coll Pharm, Kwangju 501759, South Korea

[2] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea

[3] Vietnam Inst Med Mat, Hanoi, Vietnam

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 12期

关键词：

INHIBITORS;

D O I：

10.1021/np200667f

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four new ent-kaurane diterpenoids (1-4) were isolated from the leaves of Croton tonkinensis by bioactivity-guided fractionation using an in vitro osteoblast differentiation assay. Their structures were identified as ent-11 beta-acetoxykaur-16-en-18-ol (1), ent-11 alpha-hydroxy-18-acetoxykaur-16-ene (2), ent-14 beta-hydroxy-18-acetoxykaur-16-ene (3), and ent-7 alpha-hydroxy-18-acetoxykaur-16-ene (4). Compounds 1-4 significantly increased alkaline phosphatase activity and osteoblastic gene promoter activity. Compounds 1-3 also increased the levels of ALP and collagen type I alpha mRNA in C2C12 cells in a dose-dependent manner. These results suggest that ent-kaurane diterpenoids from C. tonkinensis have a direct stimulatory effect on osteoblast differentiation and may be potential therapeutic molecules against bone diseases such as osteoporosis.

引用

页码：2526 / 2531

页数：6

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