Foxn4 directly regulates tbx2b expression and atrioventricular canal formation

被引：282

作者：

Chi, Neil C. ^{[1
,2
,3
,4
]}

Shaw, Robin M. ^{[3
,4
]}

De Val, Sarah ^{[4
]}

Kang, Guson ^{[1
,2
,3
,4
]}

Jan, Lily Y. ^{[1
,2
,4
,5
]}

Black, Brian L. ^{[1
,2
,4
]}

Stainier, Didier Y. R. ^{[1
,2
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, Program Dev Biol, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, Program Genet & Human Genet, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[5] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Physiol, San Francisco, CA 94158 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 06期

关键词：

atrioventricular canal; evolutionary development; Forkhead transcription factors; T-box transcription factors; calcium indicator; mutations;

D O I：

10.1101/gad.1629408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiac chamber formation represents an essential evolutionary milestone that allows for the heart to receive (atrium) and pump (ventricle) blood throughout a closed circulatory system. Here, we reveal a novel transcriptional pathway between foxn4 and tbx genes that facilitates this evolutionary event. We show that the zebrafish gene slipjig, which encodes Foxn4, regulates the formation of the atrioventricular (AV) canal to divide the heart. sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal.

引用

页码：734 / 739

页数：6

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