Treatment satisfaction with inhaled insulin in patients with type 1 diabetes - A randomized controlled trial

被引:78
作者
Gerber, RA
Cappelleri, JC
Kourides, IA
Gelfand, RA
机构
[1] Pfizer Inc, Global Res & Dev, Groton, CT 06340 USA
[2] Pfizer Inc, New York, NY USA
关键词
D O I
10.2337/diacare.24.9.1556
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - in patients with type I diabetes, glycemic control can be achieved as effectively with an inhaled insulin regimen, comprising preprandial inhaled intrapulmonary insulin plus a bedtime ultralente injection, as with a conventional subcutaneous insulin regimen involving two to three injections per day. Our objective was to compare patient satisfaction between inhaled insulin and subcutaneous insulin. RESEARCH DESIGN AND METHODS - Subjects with type 1 diabetes participated in a 12-week open-label trial and were randomized to either an inhaled insulin regimen or a subcutaneous insulin regimen. Subjects (n = 69) were asked to complete a 15-item self-administered satisfaction questionnaire, the Patient Satisfaction with Insulin Therapy (PSIT) Questionnaire, at baseline and week 12. Outcomes included mean percentage changes in global (overall) satisfaction and two subscales: convenience/ease of use and social comfort, RESULTS - The mean percentage improvement in overall satisfaction with inhaled insulin (35.1%, 95% Cl 18.0-52.2)was greater than with subcutaneous insulin (10.6%, 4.7-16.5) (P < 0.01), as was the improvement in convenience/ease of use: inhaled insulin 41.3% (22.9-59.6) versus subcutaneous insulin 11.2% (4.1-18.3; P < 0.01). Improvement in social comfort Was The 12-week change in HbA(1c), greater with inhaled insulin but was not statistically significant Th was associated with improved overall satisfaction (r = -0.27, P = 0.04). CONCLUSIONS - Inhaled insulin may offer the first practical, noninvasive alternative to insulin injections. For patients, vith type I diabetes, inhaled insulin maintains glycemic control and Provides greater overall satisfaction and convenience/ease of use than subcutaneous insulin.
引用
收藏
页码:1556 / 1559
页数:4
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