Cell migration/chemotaxis: Biphasic dose responses

被引：19

作者：

Calabrese, EJ ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2001年 / 31卷 / 4-5期

关键词：

cell migration; chemotaxis; hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated;

D O I：

10.1080/20014091111875

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

The dose-dependent effects of chemoattractants on target cell migration such as tumor cells, fibroblasts, and especially neutrophils were assessed. In general, the dose-response characteristics were strikingly biphasic in nature and were independent of both the target tissue and chemoattractant agent. The assessment included evaluations of the quantitative features of the dose-response relationship, mechanistic foundations of the biphasic responsiveness and clinical applications.

引用

页码：615 / 624

页数：10

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