Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer

被引：659

作者：

Ghosh, A

Heston, WDW

机构：

[1] Cleveland Clin Fdn, Dept Canc Biol, Glickman Urol Inst, Cleveland, OH 44195 USA

[2] Lerner Res Inst, Dept Canc Biol, George M O Brien Ctr Urol Res, Cleveland, OH USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2004年 / 91卷 / 03期

关键词：

prostate specific membrane antigen; carboxypeptidase; folate hydrolase; folylpoly-gamma-glutamate; dileucine motif; internalization;

D O I：

10.1002/jcb.10661

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression of PSMA makes it an important marker as well as a large extracellular target of imaging agents. PSMA can serve as target for delivery of therapeutic agents such as cytotoxins or radionuclides. PSMA has two unique enzymatic functions, folate hydrolase and NAALADase and found to be recycled like other membrane bound receptors through clathrin coated pits. The internalization property of PSMA leads one to consider the potential existence of a natural ligand for PSMA. In this review we have discussed the regulation of PSMA expression within the cells, and significance of its expression in prostate cancer and metastasis. (C) 2003 Wiley-Liss, Inc.

引用

页码：528 / 539

页数：12

共 46 条

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