The caregene study:: muscle-specific creatine kinase gene and aerobic power in coronary artery disease

被引：5

作者：

Defoor, J

Martens, K

Matthijs, G

Zieliñska, D

Schepers, D

Philips, T

Vlietinck, R

Fagard, R

Vanhees, L

机构：

[1] Univ Hosp Louvain, Dept Rehabil Sci, Cardiovasc Rehabil Unit, B-3000 Louvain, Belgium

[2] Univ Hosp Louvain, Ctr Human Genet, B-3000 Louvain, Belgium

[3] Katholieke Univ Leuven, Dept Human Genet, Louvain, Belgium

[4] Katholieke Univ Leuven, Hypertens & Cardiovasc Rehabil Unit, Dept Mol & Cardiovasc Res, Louvain, Belgium

[5] Med Univ Gdansk, Dept Rehabil, Gdansk, Poland

来源：

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION | 2005年 / 12卷 / 04期

关键词：

creatine kinase; exercise; gene; muscle; oxygen uptake; polymorphism; rehabilitation; training;

D O I：

10.1097/01.hjr.0000170266.30562.59

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 927 biologically unrelated Caucasian patients with coronary artery disease it was investigated whether the Ncol restriction fragment length polymorphism of the muscle-specific creatine kinase (CKMM) gene is associated with aerobic power and with the response to physical training. Physical training significantly (P < 0.001) increased peak oxygen consumption in the GG, AG and AA Ncol genotypes. Covariate-adjusted peak oxygen consumption at baseline, after training and the response to training were not different across CKMM Ncol genotypes.

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收藏

页码：415 / 417

页数：3

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