Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines

被引:57
作者
Chang, CI
Kuo, CC
Chang, JY
Kuo, YH [1 ]
机构
[1] Natl Pingtung Univ Sci & Technol, Grad Inst Biotechnol, Pingtung 912, Taiwan
[2] Natl Hlth Res Inst, Div Canc Res, Taipei 115, Taiwan
[3] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
来源
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 01期
关键词
D O I
10.1021/np030267m
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC50 values in the range 1.2-3.6 muM.
引用
收藏
页码:91 / 93
页数:3
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