Optical resolution of new quinolone drugs by capillary electrophoresis with ligand-exchange and host-guest interactions

被引：60

作者：

Horimai, T

Ohara, M

Ichinose, M

机构：

[1] Analytical Research Center, Prod. Technol. Res. Laboratories, Daiichi Pharmaceutical Co., Ltd, 1-16-13, Kitakasai Edogawa-ku

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 760卷 / 02期

关键词：

enantiomer separation; buffer composition; pharmaceutical analysis; quinolones; ofloxacin;

D O I：

10.1016/S0021-9673(96)00787-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method for the optical resolution of new quinolone drugs (NQs) by capillary electrophoresis has been investigated. The NQs were adequately resolved using a gamma-cyclodextrin (gamma-CD)-Zn(II)-D-phenylalanine (D-Phe) solution as the running solution. The resolution depended on the components of the running solution and their concentrations. When L-Phe was used instead of D-Phe, inversion of the migration order of the enantiomers was observed. The resolution mechanism is considered to be due to a ligand-exchange interaction of the NQs with Zn(II) and D-Phe, in combination with a host-guest interaction of those with gamma-CD.

引用

页码：235 / 244

页数：10

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