Working memory in Parkinson's disease patients

被引：41

作者：

Beato, Rogerio ^{[1
,4
]}

Levy, Richard ^{[2
,4
]}

Pillon, Bernard ^{[2
,4
]}

Vidal, Christine ^{[4
]}

du Montcel, Sophie Tezenas ^{[3
]}

Deweer, Bernard ^{[4
]}

Bonnet, Anne-Marie ^{[2
]}

Houeto, Jean-Luc ^{[2
]}

Dubois, Bruno ^{[2
,4
]}

Cardoso, Francisco ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Neurol Serv, Fac Med, Dept Clin Med, BR-30150290 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Fac Med, Fed Neurol, BR-30150290 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Med, Serv Informat Med, Dept Biostat, BR-30150290 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Fac Med, INSERM U610, BR-30150290 Belo Horizonte, MG, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2008年 / 66卷 / 2A期

关键词：

Parkinson's disease; striatum; executive functions; working memory; levodopa;

D O I：

10.1590/S0004-282X2008000200001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Objective: To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM. Method: The paradigm was based on the 'n-back' tasks, which enables to study the level of executive demand (three levels of difficulty) and the domain of the information being processed (spatial items, faces and letters). The effect of levodopa was studied by testing PD patients in "on" and "off" states. Results: PD patients performed less well in WM tasks than controls. There was no interaction between groups and complexity. Levodopa therapy had a positive effect only on spatial WM tasks but no effect on complexity. Conclusion: Our results suggest that impairment observed may result from a maintenance deficit within WM regardless the level of processing and levodopa therapy presents a positive effect on spatial WM.

引用

页码：147 / 151

页数：5

共 30 条

[1]

PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].

ALEXANDER, GE ;

DELONG, MR ;

STRICK, PL .

ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381

[2]

Working memory [J].

Baddeley, Alan .

CURRENT BIOLOGY, 2010, 20 (04) :R136-R140

[3]

Cohen J D, 1994, Hum Brain Mapp, V1, P293, DOI 10.1002/hbm.460010407

[4]

Dopaminergic modulation of visual-spatial working memory in Parkinson's disease [J].

Costa, A ;

Peppe, A ;

Dell'Agnello, G ;

Carlesimo, GA ;

Murri, L ;

Bonuccelli, U ;

Caltagirone, C .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2003, 15 (02) :55-66

[5]

DUBOIS B, 1992, PARKINSONS DIS NEURO, P178

[6]

Fahn S, 1987, Recent Dev. Park. Dis, P153

[7]

BEHAVIORAL AND NEUROCHEMICAL EFFECTS FOLLOWING NEUROTOXIC LESIONS OF A MAJOR CHOLINERGIC INPUT TO THE CEREBRAL-CORTEX IN THE RAT [J].

FLICKER, C ;

DEAN, RL ;

WATKINS, DL ;

FISHER, SK ;

BARTUS, RT .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1983, 18 (06) :973-981

[8]

Reduced working memory span in Parkinson's disease: Evidence for the role of a frontostriatal system in working and strategic memory [J].

Gabrieli, JDE ;

Singh, J ;

Stebbins, GT ;

Goetz, CG .

NEUROPSYCHOLOGY, 1996, 10 (03) :322-332

[9]

PARKINSONISM - ONSET PROGRESSION AND MORTALITY [J].

HOEHN, MM ;

YAHR, MD .

NEUROLOGY, 1967, 17 (05) :427-&

[10]

ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

← 1 2 3 →