Enhancing central nervous system remyelination in multiple sclerosis

被引：92

作者：

Dubois-Dalcq, M ^{[1
]}

Ffrench-Constant, C

Franklin, RJM

机构：

[1] NINDS, NIH, Bethesda, MD 20892 USA

[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1TN, England

[3] Univ Cambridge, Dept Vet Med, Cambridge CB2 1TN, England

[4] Univ Cambridge, Cambridge Ctr Brain Repair, Cambridge CB2 1TN, England

来源：

NEURON | 2005年 / 48卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2005.09.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies on adult neural stem cells and the developmental biology of myelination have generated the expectation that neural precursors can repair the damaged central nervous system of multiple sclerosis patients where the endogenous remyelination process has failed. As a result, many laboratories are engaged in translational studies in which the goal is to design ways to promote remyelination and repair. Here we raise issues highlighted by prior experimental and human work that should be considered lest these studies become "lost in translation."

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页码：9 / 12

页数：4

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