Ruthenium(II) in ring closing metathesis for the stereoselective preparation of cyclic 1-amino-1-carboxylic acids.

被引：77

作者：

Hammer, K ^{[1
]}

Undheim, K ^{[1
]}

机构：

[1] UNIV OSLO, DEPT CHEM, N-0315 OSLO, NORWAY

来源：

TETRAHEDRON | 1997年 / 53卷 / 06期

关键词：

D O I：

10.1016/S0040-4020(96)01132-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective synthesis of alpha-amino acids where the alpha-carbon of the amino acid is incorporated into a five-, six- or seven-membered ring is described. The stereoselective control results from stepwise bisalkenylation of (R)-25-dihydro-3,6-dimethoxy-2-isopropylpyrazine. Ring closing metathesis was effected by ruthenium(II)-catalysis. The spiro-cycloalkene intermediates were further transformed into 1-aminocycloalkene-1-carboxylic acid derivatives by mild add hydrolysis. (C) 1997, Elsevier Science Ltd.

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页码：2309 / 2322

页数：14

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