Oxidative stress in the newborn - A 30-year perspective

被引:260
作者
Saugstad, OD [1 ]
机构
[1] Univ Oslo, Rikshosp, Fac Div,Dept Pediat Res, Pediat Forsknings Inst, NO-0027 Oslo, Norway
来源
BIOLOGY OF THE NEONATE | 2005年 / 88卷 / 03期
关键词
hypoxia-reoxygenation injury; newborn infants; oxidative stress;
D O I
10.1159/000087586
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In this review the development of the concept 'hypoxia-reoxygenation injury' is outlined. An update of some important factors and mechanisms related to oxidative stress injury in newborn infants is presented, including the metabolism of glutathione, the role of antioxidants, iron and nitric oxide, and how these may influence health and disease in the newborn and contribute to 'oxygen radical disease of the newborn'. New insight into how hyperoxia and hypoxia may induce changes leading to retinopathy of prematurity by vascular endothelial growth factor acting in concert with insulin-like growth factor is briefly summarized. Inflammation and oxidative stress seem to be two sides of the same coin in newborn babies both contributing to injury partly through similar mechanisms. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码:228 / 236
页数:9
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