Immunological properties of human embryonic stem cell-derived oligodendrocyte progenitor cells

被引：49

作者：

Okamura, Ross M. ^{[1
]}

Lebkowski, Jane ^{[1
]}

Au, Melinda ^{[1
]}

Priest, Catherine A. ^{[1
]}

Denham, Jerrod ^{[1
]}

Majumdar, Anish S. ^{[1
]}

机构：

[1] Geron Corp, Menlo Pk, CA 94025 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 192卷 / 1-2期

关键词：

allogenicity; embryonic stem cells; Neu5Gc; oligodendrocyte progenitors;

D O I：

10.1016/j.jneuroim.2007.09.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A major concern in the use of allotransplantation of human embryonic stem cell (hESC)-based therapies is the possibility of allogeneic rejection by the host's immune system. In this report, we determined the immunological properties of hESC-derived oligodendrocyte progenitor cells (OPC) that have the potential for clinical application for the treatment of patients with spinal cord injury. In vitro immunological studies suggest that hESC-derived OPCs are poor targets for both the innate and the adaptive human immune effector cells as well as resistant to lysis by anti-Neu5Gc antibodies. These results indicate that hESC-derived OPCs retain some of the unique immunological properties of the parental cell line from which they were differentiated. (c) 2007 Elsevier BN. All rights reserved.

引用

收藏

页码：134 / 144

页数：11

相关论文

共 49 条

[1] Modulation of atherogenesis by chemokines [J].

Boisvert, WA .

TRENDS IN CARDIOVASCULAR MEDICINE, 2004, 14 (04) :161-165

[2] The human natural cytotoxicity receptors (NCR) that induce HLA class I-independent NK cell triggering [J].

Bottino, C ;

Biassoni, R ;

Millo, R ;

Moretta, L ;

Moretta, A .

HUMAN IMMUNOLOGY, 2000, 61 (01) :1-6

[3] Enrichment of neurons and neural precursors from human embryonic stem cells [J].

Carpenter, MK ;

Inokuma, MS ;

Denham, J ;

Mujtaba, T ;

Chiu, CP ;

Rao, MS .

EXPERIMENTAL NEUROLOGY, 2001, 172 (02) :383-397

[4]

Cerdan C, 2006, NAT MED, V12, P1113, DOI 10.1038/nm1006-1113

[5] Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells [J].

D'Amour, Kevin A. ;

Bang, Anne G. ;

Eliazer, Susan ;

Kelly, Olivia G. ;

Agulnick, Alan D. ;

Smart, Nora G. ;

Moorman, Mark A. ;

Kroon, Evert ;

Carpenter, Melissa K. ;

Baetge, Emmanuel E. .

NATURE BIOTECHNOLOGY, 2006, 24 (11) :1392-1401

[6] Urokinase induces basophil chemotaxis through a urokinase receptor or epitope that is an endogenous ligand for formyl peptide receptor-like 1 and -like 2 [J].

de Paulis, A ;

Montuori, N ;

Prevete, N ;

Fiorentino, I ;

Rossi, FW ;

Visconte, V ;

Rossi, G ;

Marone, G ;

Ragno, P .

JOURNAL OF IMMUNOLOGY, 2004, 173 (09) :5739-5748

[7] Regeneration of descending axon tracts after spinal cord injury [J].

Deumens, R ;

Koopmans, GC ;

Joosten, EAJ .

PROGRESS IN NEUROBIOLOGY, 2005, 77 (1-2) :57-89

[8] LYMPHOID DEVELOPMENT IN MICE WITH A TARGETED DELETION OF THE INTERLEUKIN-2 RECEPTOR-GAMMA CHAIN [J].

DISANTO, JP ;

MULLER, W ;

GUYGRAND, D ;

FISCHER, A ;

RAJEWSKY, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :377-381

[9] Surface antigens of human embryonic stem cells: changes upon differentiation in culture [J].

Draper, JS ;

Pigott, C ;

Thomson, JA ;

Andrews, PW .

JOURNAL OF ANATOMY, 2002, 200 (03) :249-258

[10] Characterization of the expression of MHC proteins in human embryonic stem cells [J].

Drukker, M ;

Katz, G ;

Urbach, A ;

Schuldiner, M ;

Markel, G ;

Itskovitz-Eldor, J ;

Reubinoff, B ;

Mandelboim, O ;

Benvenisty, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :9864-9869

← 1 2 3 4 5 →