How ATR turns on: TopBP1 goes on ATRIP with ATR

被引：61

作者：

Burrows, Anna E. ^{[1
]}

Elledge, Stephen J. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet,Howard Hughes Med Inst, Ctr Genet & Genom,Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 11期

关键词：

ATR; ATRIP; TopBP1; checkpoint; PIKK; Ddc2;

D O I：

10.1101/gad.1685108

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this issue of Genes & Development, Mordes and colleagues (pp. 1478-1489) reveal intriguing mechanistic insights into activation of the ATR (ATM and Rad3-related) kinase critical for DNA damage resistance. They identify conserved regulatory domains within ATR and its binding partner ATRIP (ATR-interacting protein), which are contacted by the ATR activator TopBP1. These discoveries expand on our understanding of the regulation of other PIKK family members, which also contain these domains, and illustrate how functional diversity has been achieved among these kinases.

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收藏

页码：1416 / 1421

页数：6

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