Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci

被引：17

作者：

HeinzeKrauss, I ^{[1
]}

Angehrn, P ^{[1
]}

Guerry, P ^{[1
]}

Hebeisen, P ^{[1
]}

Hubschwerlen, C ^{[1
]}

Kompis, I ^{[1
]}

Page, MGP ^{[1
]}

Richter, HGF ^{[1
]}

Runtz, V ^{[1
]}

Stalder, H ^{[1
]}

Weiss, U ^{[1
]}

Wei, CC ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,NUTLEY,NJ 07110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 09期

关键词：

D O I：

10.1021/jm950886v

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.

引用

页码：1864 / 1871

页数：8

共 29 条

[21] STUDIES ON BETA-LACTAM ANTIBIOTICS .3. SYNTHESES AND ANTIBACTERIAL ACTIVITIES OF NEW 3-(1,3-DITHIOLAN-2-YL)CEPHALOSPORINS, YM-22508, YM-16457 AND THEIR PRODRUG-TYPE ESTERS [J].