Cell-derived microparticles in atherosclerosis: biomarkers and targets for pharmacological modulation?

被引：59

作者：

Baron, Morgane ^{[1
,2
,3
]}

Boulanger, Chantal M. ^{[4
,5
]}

Staels, Bart ^{[1
,2
,3
]}

Tailleux, Anne ^{[1
,2
,3
]}

机构：

[1] Inst Pasteur, INSERM, U1011, F-59019 Lille, France

[2] Univ Lille Nord France, Lille, France

[3] UDSL, Lille, France

[4] Paris Cardiovasc Res Ctr PARCC, INSERM, U970, Paris, France

[5] Univ Paris 05, UMR 970, Paris, France

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2012年 / 16卷 / 07期

关键词：

microparticles; biomarkers; cardiovascular diseases; TYPE-2; DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE; CIRCULATING ENDOTHELIAL MICROPARTICLES; SHED MEMBRANE MICROPARTICLES; ANGIOGENESIS IN-VITRO; TISSUE-FACTOR; PLATELET MICROPARTICLES; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; HYPERTENSIVE PATIENTS;

D O I：

10.1111/j.1582-4934.2011.01486.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiovascular diseases remain an important cause of morbi-mortality. Atherosclerosis, which predisposes to cardiovascular disorders such as myocardial infarction and stroke, develops silently over several decades. Identification of circulating biomarkers to evaluate cardiovascular event risk and pathology prognosis is of particular importance. Microparticles (MPs) are small vesicles released from cells upon apoptosis or activation. Microparticles are present in blood of healthy individuals. Studies showing a modification of their concentrations in patients with cardiovascular risk factors and after cardiovascular events identify MPs as potential biomarkers of disease. Moreover, the pathophysiological properties of MPs may contribute to atherosclerosis development. In addition, pharmacological compounds, used in the treatment of cardiovascular disease, can reduce plasma MP concentrations. Nevertheless, numerous issues remain to be solved before MP measurement can be applied as routine biological tests to improve cardiovascular risk prediction. In particular, prospective studies to identify the predictive values of MPs in pathologies such as cardiovascular diseases are needed to demonstrate whether MPs are useful biomarkers for the early detection of the disease and its progression.

引用

页码：1365 / 1376

页数：12

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