The gastrointestinal transit profile of 14C-labelled poly(acrylic acids):: an in vivo study

被引：34

作者：

Riley, RG

Green, KL

Smart, JD

Tsibouklis, J

Davis, JA

Hampson, F

Dettmar, PW

Wilber, WR

机构：

[1] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England

[2] Reckitt Benckiser Ltd, Hull HU8 7DS, N Humberside, England

[3] BF Goodrich Performance Mat, Brecksville, OH 44141 USA

来源：

BIOMATERIALS | 2001年 / 22卷 / 13期

关键词：

C-14-poly(acrylic acid); in vivo; polymer retention; mucoadhesion;

D O I：

10.1016/S0142-9612(00)00369-0

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The gastrointestinal distribution profiles for three C-14-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1861 / 1867

页数：7

共 13 条

[1] IN-VITRO AND IN-VIVO EVALUATION OF MUCOADHESIVE MICROSPHERES PREPARED FOR THE GASTROINTESTINAL-TRACT USING POLYGLYCEROL ESTERS OF FATTY-ACIDS AND A POLY(ACRYLIC ACID) DERIVATIVE [J].