Parthenolide Induces Apoptosis and Cell Cycle Arrest of Human 5637 Bladder Cancer Cells In Vitro

被引：41

作者：

Cheng, Guang ^{[1
]}

Xie, Liping ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Urol, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China

来源：

MOLECULES | 2011年 / 16卷 / 08期

关键词：

bladder cancer; parthenolide; cell cycle arrest; apoptosis; NF-KAPPA-B; SESQUITERPENE LACTONES; ACTIVATION; INHIBITION; P53; PROLIFERATION; FEVERFEW; GROWTH; DEATH; LUNG;

D O I：

10.3390/molecules16086758

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Parthenolide, the principal component of sesquiterpene lactones present in medical plants such as feverfew (Tanacetum parthenium), has been reported to have anti-tumor activity. In this study, we evaluated the therapeutic potential of parthenolide against bladder cancer and its mechanism of action. Treatment of bladder cancer cells with parthenolide resulted in a significant decrease in cell viability. Parthenolide induced apoptosis through the modulation of Bcl-2 family proteins and poly (ADP-ribose) polymerase degradation. Treatment with parthenolide led to G1 phase cell cycle arrest in 5637 cells by modulation of cyclin D1 and phosphorylated cyclin-dependent kinase 2. Parthenolide also inhibited the invasive ability of bladder cancer cells. These findings suggest that parthenolide could be a novel therapeutic agent for treatment of bladder cancer.

引用

页码：6758 / 6768

页数：11

共 29 条

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ACTIVATION OF POLY(ADP-RIBOSE)POLYMERASE IN APOPTOTIC HUMAN-CELLS [J].